CanLncG4, an intricately curated database, presents 17,666 experimentally-validated associations between 6,408 human long non-coding RNAs (lncRNAs), including their transcript variants, and 15 distinct types of human cancers, while predicting their G-quadruplex (G4)-forming potential. This database furnishes a comprehensive G4-prediction analysis for each transcript variant, categorizing the anticipated G4 types (2G, 3G, and 4G). Moreover, integrated standalone G4-prediction tools empower users to critically assess, categorize, and compare G4-predictions for any given sequence. CanLncG4 also affords insights into the subcellular localization of catalogued lncRNAs across diverse cell lines and undertakes an exhaustive meta-analysis of interaction partners (RNA and protein) linked to catalogued lncRNAs based on the most recent available data. Additionally, the database imparts information concerning the established G4-binding capabilities of proteins that interact with the catalogued lncRNAs. CanLncG4 utilizes meticulous meta-analyses of data from reputable sources and specialized tools, such as Lnc2cancer3.0, GeneCards, NCBI Nucleotide, QGRS mapper, G4Hunter, LncATLAS, NPInter v4.0, LncTarD 2.0, QUADRatlas, G4IPDB, and scientific literature mining. The development of CanLncG4 endeavours to standardize the assimilation of information regarding the G4-forming potential of dysregulated lncRNAs in human cancers, offering invaluable insights into both lncRNA interactions and G4-associated proteins.
Example: LncRNA name: "MALAT1" or Cancer name: "Colorectal Cancer"